Subspace-optimal data mining on spatially adaptive sparse grids

Continued improvements in technology lead to an ever-growing amount of data generated, for example, by scientific measurements and simulations. Data-mining is required to gain useful knowledge from this data, however, can be challenging especially due to the size and dimensionality of these problems. The use of regular grids for such applications is often limited by the curse of dimensionality, a phrase used to describe an exponential dependency of the computational complexity of a problem on the dimensionality of this problem. For many higher-dimensional problems, e.g. with 28 dimensions, regular grids cannot be used to compute results with the desired accuracy in a reasonable amount of time, even if the memory required to store and process them is available. With spatially adaptive sparse grids, this problem can be overcome, as they lessen the influence of the dimensionality on the size of the grid, furthermore, they have been successfully applied for many tasks, including regression on large data sets. However, the currently preferred and in practice highly performant streaming-algorithm for regression on spatially adaptive sparse grids employs many unnecessary operations to effectively utilize modern parallel computer architectures, such as graphics processing units (GPUs). In this thesis, we show that the implementation of a by computational complexity more promising subspace-linear algorithm on the GPU is able to out-perform the currently preferred streaming-algorithm on many scenarios, even though the this algorithm does not utilize modern architectures as well as the streaming-algorithm. Furthermore, we explore the construction of a new algorithm by combining both, streaming- and subspace-linear algorithm, which aims to process each subgrid of the grid with the algorithm deemed most efficient for its structure. We evaluated both of our algorithms against the highly optimized implementation of the streaming-algorithm provided in the SG++ framework, and could indeed show speed-ups for both algorithms, depending on the experiments

Amodal Optical Flow

Optical flow estimation is very challenging in situations with transparent or occluded objects. In this work, we address these challenges at the task level by introducing Amodal Optical Flow, which integrates optical flow with amodal perception. Instead of only representing the visible regions, we define amodal optical flow as a multi-layered pixel-level motion field that encompasses both visible and occluded regions of the scene. To facilitate research on this new task, we extend the AmodalSynthDrive dataset to include pixel-level labels for amodal optical flow estimation. We present several strong baselines, along with the Amodal Flow Quality metric to quantify the performance in an interpretable manner. Furthermore, we propose the novel AmodalFlowNet as an initial step toward addressing this task. AmodalFlowNet consists of a transformer-based cost-volume encoder paired with a recurrent transformer decoder which facilitates recurrent hierarchical feature propagation and amodal semantic grounding. We demonstrate the tractability of amodal optical flow in extensive experiments and show its utility for downstream tasks such as panoptic tracking. We make the dataset, code, and trained models publicly available at http://amodal-flow.cs.uni-freiburg.de

Colombia: Doctoral Excursion, Earth Sciences Department ETH Zurich, August 21 – September 5, 2018

Field guide of Doctoral Excursion to Colombia, co-organized by Luz M. Mejia, R.Ott, L. Echeverria-Pazos, E. Erlanger. Chapter 11: Climate Change Effects on Colombian Biodiversity written by Luz M. Mejia and B. Revels

A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy

Background: Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible for the high risk of MAFLD-related HCC. We analyzed the impact of the proto-oncogene c-MYC in the development of human and murine MAFLD and MAFLD-associated HCC. Methods: alb-myctg mice were studied at baseline conditions and after administration of Western diet (WD) in comparison to WT littermates. c-MYC expression was analyzed in biopsies of patients with MAFLD and MAFLD-associated HCC by immunohistochemistry. Results: Mild obesity, spontaneous hyperlipidaemia, glucose intolerance and insulin resistance were characteristic of 36-week-old alb-myctg mice. Middle-aged alb-myctg exhibited liver steatosis and increased triglyceride content. Liver injury and inflammation were associated with elevated ALT, an upregulation of ER-stress response and increased ROS production, collagen deposition and compensatory proliferation. At 52 weeks, 20% of transgenic mice developed HCC. WD feeding exacerbated metabolic abnormalities, steatohepatitis, fibrogenesis and tumor prevalence. Therapeutic use of metformin partly attenuated the spontaneous MAFLD phenotype of alb-myctg mice. Importantly, upregulation and nuclear localization of c-MYC were characteristic of patients with MAFLD and MAFLD-related HCC. Conclusions: A novel function of c-MYC in MAFLD progression was identified opening new avenues for preventative strategies

A search for ultra-high-energy photons at the Pierre Auger Observatory exploiting air-shower universality

The Pierre Auger Observatory is the most sensitive detector to primary photons with energies above ∼0.2 EeV. It measures extensive air showers using a hybrid technique that combines a fluorescence detector (FD) with a ground array of particle detectors (SD). The signatures of a photon-induced air shower are a larger atmospheric depth at the shower maximum (X$_{max}$) and a steeper lateral distribution function, along with a lower number of muons with respect to the bulk of hadron-induced background. Using observables measured by the FD and SD, three photon searches in different energy bands are performed. In particular, between threshold energies of 1-10 EeV, a new analysis technique has been developed by combining the FD-based measurement of X$_{max}$ with the SD signal through a parameter related to its muon content, derived from the universality of the air showers. This technique has led to a better photon/hadron separation and, consequently, to a higher search sensitivity, resulting in a tighter upper limit than before. The outcome of this new analysis is presented here, along with previous results in the energy ranges below 1 EeV and above 10 EeV. From the data collected by the Pierre Auger Observatory in about 15 years of operation, the most stringent constraints on the fraction of photons in the cosmic flux are set over almost three decades in energy

Study on multi-ELVES in the Pierre Auger Observatory

Since 2013, the four sites of the Fluorescence Detector (FD) of the Pierre Auger Observatory record ELVES with a dedicated trigger. These UV light emissions are correlated to distant lightning strikes. The length of recorded traces has been increased from 100 μs (2013), to 300 μs (2014-16), to 900 μs (2017-present), to progressively extend the observation of the light emission towards the vertical of the causative lightning and beyond. A large fraction of the observed events shows double ELVES within the time window, and, in some cases, even more complex structures are observed. The nature of the multi-ELVES is not completely understood but may be related to the different types of lightning in which they are originated. For example, it is known that Narrow Bipolar Events can produce double ELVES, and Energetic In-cloud Pulses, occurring between the main negative and upper positive charge layer of clouds, can induce double and even quadruple ELVES in the ionosphere. This report shows the seasonal and daily dependence of the time gap, amplitude ratio, and correlation between the pulse widths of the peaks in a sample of 1000+ multi-ELVES events recorded during the period 2014-20. The events have been compared with data from other satellite and ground-based sensing devices to study the correlation of their properties with lightning observables such as altitude and polarity

Extraction of the Muon Signals Recorded with the Surface Detector of the Pierre Auger Observatory Using Recurrent Neural Networks

We present a method based on the use of Recurrent Neural Networks to extract the muon component from the time traces registered with water-Cherenkov detector (WCD) stations of the Surface Detector of the Pierre Auger Observatory. The design of the WCDs does not allow to separate the contribution of muons to the time traces obtained from the WCDs from those of photons, electrons and positrons for all events. Separating the muon and electromagnetic components is crucial for the determination of the nature of the primary cosmic rays and properties of the hadronic interactions at ultra-high energies. We trained a neural network to extract the muon and the electromagnetic components from the WCD traces using a large set of simulated air showers, with around 450 000 simulated events. For training and evaluating the performance of the neural network, simulated events with energies between 1018.5, eV and 1020 eV and zenith angles below 60 degrees were used. We also study the performance of this method on experimental data of the Pierre Auger Observatory and show that our predicted muon lateral distributions agree with the parameterizations obtained by the AGASA collaboration